Detoxificación hepática y defensa antioxidante por efecto de xenobióticos

BJORNEBOE, A.; BJORNEBOE, G. E. and DREVON, C. A. Absorption, transport and distribution of vitalmine E. J. Nutr. Vol. 120: 233-242, 1990.
BRADLEY, D. How to spot nitric oxide in the body. Science, pp 15, June 12, 1993.

	Ficha de Tesis
	Tabla de contenido

BRADY, P. S.; BRADY, L. J. and ULTREY, D. E. Solenium, vitamine E and the response to swimming stress in the rat. J. Nut. Vol. 109, 1 103, 1979.
BUCKINGHAM, K. W. Effect of dietary polynsaturated/ saturated fatty acid ratio and dietary vitamin E on lipid peroxidation In the rat. J Nut. Vol. 115, 1 425-1 435, 195.
BUEGE, J. A. and AUST, S. D. Microsomal lipid peroxidation. Methods in Enzymology. Vol 52, 302-310, 1978.
BURTON, G.; JOYCE, A. and INGOLD, K. Is vitamine E the only lipid -soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes. Arch. Biochem. Biophys., Vol. 21, 281-290, 1983.
BURTON, S. and TRABER, M. Vitamine E antioxidant activity biokinetics and bioavailability. Arin. Rey. Nutril Vol 10, 357-38, 1990.
CADENAS, E. Biochemistry of oxigen toxicity. Ann. Rey. Bioch Vol, 8, 79-110. 1989.
CAMPOS, R.; GARRIDO, A.; GUERRA, R. and VALENZUELA, A. Increased resistance against oxidativo stress la observed during a short period of renal reperfusion after a temporal ischaemia. Free Rad Res. Comms. Vol 10, 259-264, 1990.
CLARK I. A. Tissue damage caused by free oxygen radicals. Patology Vol. 18, 181-186, 1986.
COMBS. G. F. Assessment of vitamine E status in animals an man. Proc. Nutr. Soc. Vol. 40. 187-194, 1981.
COTGREAVE, I.; MOWEUS, P and ORRENIUS, S. Host biochemical defense mechanisms against pro-oxidants Ann. Rev Phsrmacol, Toxicol. Vol. 28, 189-212. 1988.
CRAPO, J. D.; MOLDEUS, P. and FRIDOVICH, I. Preparation and essay of superoxide dismutases. Methods In Enzymology Vol. 53, 382-393, 1978.
CROSS, C. C. Oxigen redicals and human disease. Davis conference. Ann. Internal Medicine, Vol. 107, 526-545. 1987.
CHEFTEL, J. C.; CHEFTEL, H. Y BESAUCON, P. Introducción a la Bioquímica y Tecnología de los alimentos. Vol 1, 1983.
CHEESEMAN, K; EMERY, S.; MADDIX, S.; SLATER, T.; BURTON, G. and INGOLDK. Studies on lipid peroxidation in normal and turnover tissues. Biochem. J. Vol. 250, 247-252, 1988.
CHEESEMAN, K. and SLATER, T. F. Free radicals In Medicine. Brit. Med. Bull. 49, 479, 724, 1993.
DELGADO, G. y MÁLAGA, D. Investigación Químico Toxicológica de nitritos, nitratos y nitrosaminas en embutidos y carne curadas. Tesis Fac. Farm. y Bioq. UNMSM. Lima, 1989.
DEMPLE, B. and AMABILOE-CUEVAS, C. F. Redox-redux: the control of oxídative stress responses. Cell. Vol 67, 837-839, 1991.
DÍAZ, J. C. y HICKS, J. J. Bioquímica o Inmunología. Fac. Medic. de la UNAM. Vol. II, 563 PP. México, 1988.
DOMENECH, J. M. Métodos estadísticos para la investigación en ciencias humanas. Editorial Herder, Barcelona, 1975.
DORMANDY, T. L. Free radical oxidation and antioxidants, Lancet, 647-650, Mach, 25 1978.
FALKAY, G.; HERCSEG, J. and SAS, M. Microsomal lipid peroxidation in human pregnant uterus and placenta. Bioch. Diophys. Res. Comm. Vol. 39. 843-851, 1977.
FLOHE, L and OTTING, F. Superoxide dismutase assays. Methods in enzimatology. Vol. 105, 1984.
GELMONT, D.; STEIN. R. and MEAD, J. The bacterial origin of rat breath pentane. Bioch. Bioph. Res. Com. Vol. 102, 932-936, 1981.
GUENGERICH, P. Effects of nutritive factors on metabolic processe involving bioactivation and detoxication of chemical. Ann Rev. Nutrit. Vol. 4, 207-231, 1984.
GUENGERICH, F. P. and UEBLER, D. C. Enzymatic activation of chemicals to toxic metabolites. CRC Critical Reviews In Toxicology, Vol. 14, 259-307, 1986.
HABIG, W. H.; PABST, M. J. and JAKOBY, W. B. Glutathione S-transferases, J. Biol. Chem. Vol 249, 7 130-7 139, 1974.
HAFEMAN, D. G. and HOEKSTRA, W. G. Lipid peroxidation in vivo during vitamine E and Se deficiency in the rat as monitorad by ethane evolution. J. Nutr. Vol. 107, 666-672, 1977.
HAGLUND, 0.; LUOSTARINEN, R.; WIBELL, L. and SALDEEN, T. The effects of fish oil on triglicerides, cholesterol, fibrinogen and malondialdeheyde in humans suplemented with vitamine E. J. Nutr. Vol, 121, 165-169, 1991.
HUBEL, C.; ROBERTS, J.; TAYLOR, R. and MC LAUGHUN, M. Lipid peroxidation in pregnancy: New perspectives on preeclamsia, Am. J. Obs. Ginecol. Vol. 161, 1 025-1 034, 1989.
KAGAN, U.; SERBINOVA, E. and PARKER, L. Antioxidant effects ofubiquinones in microsomal and mitochondria are mediated by tocopherol recycling. B. B. R. C. Vopl. 169, 851-857, 1990.
KAPPUS, H. Oxidative stress in chemical toxicity. Arch. Toxicol. Vol. 60, 144-149, 1987.
LOWRY, O. H.; ROSEBROUGH, N. J.; FARR, A. L. and RANDALL R. J. Determination of proteins. J. Biol. Chem. Vol. 193, 265-275, 1951.
MC CORD, J. and FRIDOVICH, I. Superoxide dismutase. J. Biol. Chem. Vol. 244, 6 049-6 055, 1969.
MCKENZIE, J. B.; ROSENKIRANTZ, H.; ULICK S. and MILHORAT, T. The biological and alfa-tocopherylhydroquinone and alfa-tocopherylquione. J. Biol. Chem. Vol. 183, 655-662, 1950.
MISRA, H. P. and FRIDOVICH, I. The role of superoxide anion in the autoxidation of epinefrine and a simple assay for superoxide dismutase. J. Biol. Chem. Vol. 247, 31 709-31 75, 1972.
PICKETT, C. and LU, A. Glutathione D-transferases. Ann. Rev. Biochem. Vol 58, 743-764, 1989.
PORTER, N. D. Chemistry of lipid peroxidation. Methods in Enzimology. Vol. 105, 273-305, 1984.
PROASKA, J. Changes in Cu, Zn-Superoxido dismutase, cytochome oxydase, gluathione peroxidase, and glutathione transferase activities in copper-deficient mico and rets. J. Nutr. Vol 121, 355-369, 1991.
ROBERTS, J. and CASERIO, M. Basic Principles of Organic Chemistry ed. W. A. Benjamin, 1 596 pp California, 1977.
ROBINSON, D. S. Bioquímica y valor nutritivo de los alimentos. ed. Acribla, 516 pp Zaragoza, 1991.
RUSSELL, J. B. Química general. ed. Mc. Graw-Will, 747 pp. Colombia, 1985.
SCHOUCH, H.; MURPHY, M. E. and SIES, H. Antioxidant activity of dihidrolipoate against microsomal lipid peroxidation and its dependence on alpha-tocopherol. BOA Vol. 1 001, 256-261, 1989.
SEIBA, K. and YOSHIOKA, T. Changes of lipid peroxidation and superoxide dismutase activity in the human placenta. Am. J. Obst. Gynec. Vol. 135, 368-371, 1979.
SEVANIAN, A. and HOCHSTEIN, P. Mechanisms and consequences of lipid peroxidation in biological systems. Ann. Rev. Nut. Vol. 5, 365-390, 1985.
SUN, M. and ZIGMZN, S. An improved spectrophometric assay for superoxide dismutase based on epnefrine autoxidation Anal. Bochem. Vol. 90, 81-89, 1978.
SWORD, J. T.; POPE, A. L. and HOEKSTRA, W. G. Endotoxin and lipid peroxidation in vitro in Selenium? and vitamine E? deficient and -adequate rat tissues. J. Nut. Vol. 121, 258-264, 1991.
TROSTLER, N.; BRADY, P.; ROMSOS, D. and LEVEILLE, G. Influence of dietary vitamine E on malondialdehyde in liver and adipose tissue and on glutation peroxidase and reductase activities in liver and erithrocytes of lean and obese (ob/ob) mice, J. Nutrit. Vol. 109, 345-352, 1979.
VALENZUELA, A. Activación metabólica: un mecanismo biológico que incrementa la toxicidad de los xonobióticos. Rev, Mad. Chile, Vol. 118, 1 028-1 034.
VALENZUELA, A. The biological significance of malondialdehyde determination in the asessment of tissue oxidative stress. Life Sciennes. Vol. 48, 301-309, 1991.
VATASSERY,G. T. In vitro oxidation of alpha-tocopherol in human platelets upon incubation with unsaturated fatty acids, diamide and superoxide. BBA Vol. 926, 160-169, 1987.
WALKER, R. Nitrates, nitrites and N-nitrosocompounds: a review of the occurrence in food and diet and the toxicological implications. Food edd. Contam. Vol 7. 717-768. 1990.
WEISS, S. J. and LO BUGLIO, A. F. Phagocyte generated oxygen matabolites and celullular injury. Lab Invest. Vol, 17, 5-16, 1982.
WHITE, R. E. and COON, M. J. Oxigen activation by cytochrome P-450. Ann Rev. Biochem. Vol 49, 315-356, 1980.
YANG, N. Y. and DESAI, D. Efect of high levels of dietary vitamina E on hematological indices and biochemical parameters in rat. J. Nutr. Vol. 107, 1 410-1 417, 1978.