SUMMARY

Objective: p53 tumor suppressor gene mutations and as consequence accumulation of p53 protein is common in early or later events in the carcinogenetic process of high number of malignant tumors, between them are included the genitals neoplasm.

In the present study we evaluated the expression of p53 protein in the cervical dysplasias and related the frequency of this protein in low, moderate and severe dysplasias as probable marker in the progression events of the dysplasias in the cervical carcinogenesis.

Materials and Methods: we studied the uterine cervix samples of 55 women with diagnosis of cervical dysplasia, 26 of them corresponded to low dysplasia (LD), 24 to moderate dysplasia (MD) and 5 to severe dysplasia (DS), all the samples were analyzed simultaneously for immunohistochemistry (IHC) to detect p53 protein immunoreaction. A case was considered positive when we observed a clear nuclear immunoreaction in dysplasic cells as the positive control.

Results: The p53 protein over-expression was showed in 27.27% of 55 cases studied, observing positive immunoreaction in 30.7% of the low dysplasias, in 25% of moderate dysplasias and in 20% of severe dysplasias.

Conclusion: The immunohistochemistry detection of the p53 protein over expression in this group of dysplasias us suggest its relation with early events en the carcinogenesis process of the uterine cervix, being necessary posterior molecular study of the p53 to shower the mutation and p53 polymorphism at codon 72 in these dysplasias, to determine its role indicating of the malignant nature of the lesion as probable marker in the cervical cancer prevention.

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