HELICOBACTER PYLORI CON OMEPRAZOL, AMOXICILINA Y CLARITROMICINA EN ESQUEMAS DE 7 Y 10
Wilson Rodríguez1, Arturo Pareja Cruz2, Luis Yushimito2, Alberto Ramírez Ramos3,4 ,
Robert H. Gilman3,4, José Watanabe Yamamoto4,5, Carlos Rodríguez Ulloa4,5, Daniel
Mendoza Requena3, José Guerra Valencia3, Julio Leey Casella3, Erick Chinga Alayo3,6,
Billie Velapatiño3, Teresa Valencia3.
AIM: The most accepted treatment for infection by Helicobacter pylori is the proton pump
inhibitor based therapy with two antibiotics. However, there is no consensus regarding the
duration. The purpose here was to compare eradication percentages in the omeprazole +
amoxicillin + clarithromycin regimen administered during 7 days versus 10 days and
confront the results with a previous 14-day* experience in Peru.
METHOD: Patients from the Central Military Hospital and Peruvian-Japanese Hospital
evidencing chronic upper gastrointestinal tract symptoms were recruited. We excluded
patients with peptic ulcer. Biopsies were taken for diagnosis, for urease and PCR tests,
culture and coloring with silver. Omeprazole + clarithromycin + amoxicillin was used
during 7 days versus 10 days. Control endoscopy was performed one month after treatment
had been completed and molecular biology techniques were used to differentiate recurrences
from new infections. Susceptibility to clarithromycin was assessed.
RESULTS: 36 patients were included in each group. Eradication was the same in both groups:
86.1% (31/36). In several patients in whom the bacteria persisted, the same initial
nucleus was found. In a previous study* using this same regimen during 14 days, a 93%
eradication was obtained. 91.18% of our samples were susceptible to clarithromycin.
CONCLUSIONS: In Peru, the omeprazole + clarithromycin + amoxicillin combination gives
results higher than 80% in the eradication of infection by Helicobacter pylori. The 7 and
10 days regimens eradicated the bacteria in 86% of our patients.
KEY WORDS: Helicobacter pylori, treatment, clinical trial.
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