Brennan TA, Leape LL. Laird N. et al.
Incidence of adverse effects and negligence in hospitalized patients: results of the
Harvard Medical Practice Study 1. N. Engl. J. Med. 1991;324:370-376.
Leape LL, Brennan T, Laird L, et al.
The nature of adverse events in hospitalized patients: results of the Harvard Medical
Practice Study 11. N Engl Jmed. 199 1; 324:377-384.
Bates DW, Cullen DL Laird N, et al.
Incidence of adverse drug events and potential adverse drug events: implications for
prevention. JAMA. 1995, 274:29-34. 01
Bates DW, Leape LL, Petrycki S.
Incidence and preventability of adverse events in hospitalized patients. J Gen Inter
Med. 1993,8:289-294.
Leape LL, Bates DWE, Cullen DJ, et al
Systems analysis of adverse drug events, JAMA. 1995~ 274:35-43.
Fernev RE, Whittington RM. Coroner's
cases of death due to errors in prescribing or giving medicines or to adverse drug
reactions: Birmingham 1986-1991 J.R. Soc. Med. 1994; 87:145-148.
Bates DW, Boyle DL, Vander Vliet MB,
Schneider J, Leape LL. Relationship between medication errors and adverse drug events J
Gen Intern Med. 1995; 10: 199-205.
Folli HL, Poole RL, Benitz WE, Russo
JC. Medication error prevention by clinical pharmacists in two childrens hospitals.
Pediatrics. 198719:719-722.
Lesar TS, Briceland LL, Delcoure K, et
al. Medication prescribing errors in a teaching hospital. JAMA. 1990;263;2329;2334.
Lesar TS, Briceland LL, Stein D.
Analysis of factors related to medication prescribing errors, JAMA. 1997;277;312-317.
Blum KV. Abel SR, Urbanski CL Pierce
JM.Medication error prevention by pharmacists. Am J. Hosp Pharm. 1998;45:1902-1903.
Stell K, Gertman PM, Crescenzi
C,Anderson J. latrogenic illness on a general medical serviceat a university hospital.
NEngIJ. Med. 1981;304:638-642.
Medication Error Study,
Philadelphia, Pa: Physicians Insurers Association of America;1993.
Dubois RW, Brook RH, Preventable
deaths: who, how often, why? Ann Intern Med. 1988;109;582-589.
Schiff GD. Hegde HK, La Cloche L.
Hryhorczuk DO. Inpatient theophylline toxicity: preventable factors. Ann Intern Med. 1991;
114:748-753.
Greenberger PA. Cranberg JA,Ganz M.
Hubler GL. A prospective evaluation of elevated serum theophyline concentrations to
determine if high concentrations are predictable Ann J. Med. 1991;91;67-73
Wu AW, Folkman S, McPhee S, Lo B. Do
house officers learn from their mistakes? JAMA 1991;265:2089-2094,
Vincer MJ. Murray JM, Yuill A, Allen A,
Evans J, Stinson D. Drug errors and incidents in a neonatal intensive care unit AJDC.
1989;143:737-740.
Edgar TA, Le DS, Cousins Do. Experience
with a national medication error reporting program. Am I Hosp Pharm 1994;51:1335-1338.
Pearson TF, Pittman DG, Lonley JM,
Grapes T, Vighotti DJ, Mullis SR. Factors associated with preventable adverse drug
reactions. Am J Hosp Pharm. 1994; 51; 2268-2272.
Schurnock GT, Guenette AL Keys TW ,
Hutchinson RW. Prescribing errors for patients about to be discharged from a university
teaching hospital. Am J Hosp Pharm. 1994;51:2288-2290.
Morril GB, Barreuther C, Screning
discharge prescripfions, Am J Hosp Pharm. 1988; 45: 1904-1905.
Chan CY, Maxwell PR, Koger CA, Garnboa
CD, Brewer JG Screeningdischarge prescriptions on a pediatric ward. Am 3 Hosp Pharm
1990;47:2060-2061.
Rupp MT, De Young M. Schondelmeyer SW.
Prescribing problems and pharmacists interactions in community practice. Med Care.
1992;30:926-940,
Beers MH, Ouslander JG, Hingold SF, et
a]. Inappropriate medications prescribing in skilled nursing facilities. Ann Intern Med.
1992; 117:684-689.
Ray WA, Griffin MR, Schaffner W, Baugh
DK, Melton J. Psychotropic drug use and the risk oh hip fracture. N Engl I Med.
1987;316:363-369.
Einerson TR. Drug related hospital
admissions, Ann Pharmacother 1993;27:832-840.
Hawkey CJ, Hodgson S, Norman A,
Daneshmend TK, Garner ST Effect of reactive pharmacy intervention on quality of hospital
prescribing. BMJ. 1990;300:986-990.
Epstein M. Calcium antagonists should
continue to be used for first line treatment of hypertension. Arch Intern Med.
1995,155:2150-2156.
Weintraub M, Singh S, Byrne L, Maharaj
K, Guttmacher L. Consequences of the 1989 New York State triplicate benzodiazepine
prescription regulations. JAMA. 1991;266:2392-2397.
Vitillo J. Lesar T. Preventing
medication prescribing errors. Ann Pharmacother. 1991; 25: 1388-1394.
Leape LL. Error in medicine. JAMA.
1994;272:1851-1957.
Lesar TS. Common prescribing errors.
Ann later Med. 1992:117:537.
Lomaestro 13L. Lesar TS. Methotrexate
prescribing errors. Ann Inter Med. 1992; 268: 2031-2032.
Lesar TS. Standardized dosing tables to
reduce errors involving highdose methylprednisolone for acute spinal cord injury. Hosp
Pharin. 1994;29:935-938,
Lomaestro BL. More on the GUSTO trial.
Ann Inter Med. 1994;121:818-819.
Leape LL. Lawthers AG, Brennan TA,
Johnson WG, Preventing medical injury. QRB Qual Rev. Bull. 1993;19:144-149.
Classen DC, Pestotnik SL. Evans S. et
al. Adverse drug events in hospitalized patients. JAMA. 1997;277:301-306.
Blumenthal D. Making medical errors
into medical treasures. JAMA. 1994;272:1867-1868.
Kahn KL. Above all do no harrii: how
shall we avoid errors in medicine? JAMA; 1995;274:75-76.
The science of making mistakes Lancet.
1995;345:871-872. Editorial.
Ferner RE. Is there a cure for drug
errors? BML 1995;311:463-464.
Leape LL. Preveting adverse drug
events. Am J Health Syst Pharro. 1995;52:379-381.
American Society of Hospital
Pharmacists. Reports. Draft guidelines on preventable medication errors. Am I Hosp Pharm.
1992,49 640-648
American Medical Association Board of
Trustees Report. Medication (Drug) Errors in Hospitails. Chicago, III: American Medical
Association, 1994.Resolution 512;1-93.
Johnston ME, Langton KB, Haynes B
Mathieu A. Effects of computerbased clinical decision support systems. JAM Med Intern Med.
199,L 120:135-141
Bates DW, Kuperman G, Teich JM.
Computerized physician order entry and quality of care. Q Manage Health Care.
1994,2:18-27.
Bates DW. 0 Neil AC, Boyle S. ct al.
Potential identifiability and preventability of adverse using information systems. I Am
Med Inform Assoc. 1994;1:404-411
Wyatt I Walton R. Computer based
prescribing. BMJ. 1995:311:1181-1182.
West DW, Levine S, Magram G, et al.
Pediatric medication order error rates related to the mode of order transmission. Arch
Pediatr Adolesc Med. 1994A48:1322-1326.
Pitterle M, Bond C, Raehl C, Franke T.
Hospital and pharmacy characteristics associated with mortality rates in United States
hospitals. Phaimacotherapy 1994,14 620-630.
Bjornsson DC, Hiner WO, Potyk RR et al.
Effect of pharmacists on health care outcomes in hospitalized patients. Am J Hosp Pharm.
1993;50 1875-1884.
McKenney JM, Wasserman AD. Effect of
advanced pharmaceutical services on the incidence of adverse drug reactions. Am I Hosp
Pharm. 1979:36:1691-1697.
Haig GM, Kiser LA. Effect of pharmacist
participation on a medical team on cost, charges and length of stay. Am J Hosp Pharm.
1991:48:1457-1462.
Johnson JA, Bootman JL. Drug related
morbidity and mortality: a cost of illness model. Arch later Med. 1995A55:1949-1956.
Schneider PJ, Gift MG, Lee Y-P,
Rothermich EA, Sill BE. Cost of medication related problems at a university hospital. Am J
Health Syst Pharm. 1995;52:2415-2418.
Cessna CB, Landes A, Foster CD,
editors. Growing Old in America: The information Series on Current Topics. Wylie (TX):
information Plus, 1990:2-69.
Select Committee on Aging, Health Care
Costs for Americas Elderly, 1977-88. Washington (DC): US Government Printing Office, 1989
(Committee Publication No 101-712).
Moellar JF, Mathiowetz NA. Prescribed
Medicines: A Summary of Use and Expeditures by Medicare Beneficiaries. Rockville (MD): US
Departament of Health and Human Services, 1989 (Publication N° PHS 89-3448)
Hale WE, May FE, Marks RG, Stewart RB.
Drug use in an ambulatory elderly population: a five-year update. Drug Intell Clin Pharm
1987; 21:530-535.
Lamy PP. Prescribing for the Elderly,
Litleton (MA): PSG Publishing, 1980: 89-108.
Montamat SC, Cisack BJ, Vestal RE.
Management of drug therapy in the elderly. N Engl J Med 1989; 321:303-309.
Cusack BJ, Vestal RE. Clinical
pharmacology: special consideration in the F , Iderly, In: Calkins E, Davis PJ, Ford AB,
editors. The Practice of Geriatrics, Philadelphia; Saunders, 1986:115-134.
Sloan EW, Luderer JR. Rational use of
drug levels. Am Earn Physician 1981; 23:122-126.
Calloway NO, Foley CF, Lagerbloom P.
Uncertainties in geriatric data. II. Organ size. I Am Geriatr See 1965; 13:20-28.
Wayne HA, Cope LH, Mutch E, Rawlins MD,
Woodhouse KW, James OF The effect of age upon liver volume and apparent liver blood flow
in healthy man. Hepatology 1989; 9:297-301.
O'Malley K, Crooks J, Duke E, Stevenson
IH. Effect of age and sex on human drug metabolism. BMI 1971; 3:607-609.
Vestal RE, Norris AH, 'robin JD, Cohen
BH, Shack NW, Andres R. Antipyrine metabolism in man: influence of age, alcohol, caffeine,
and smoking. Clin Pharmacol Tber 1975; 18:425-432.
Davies DF, Shock NW. Age changes in
glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in
adult males. J Clin Invest 1950; 29:496-507.
Rowe JW, ANdres R, Tobin JD, Norris AH,
Shock NW. The effect of age on creatinine clearance in men: a cross-sectional and
longitudinal study. I Gerontol 1976;31:155-163.
Cockcroft DW, Gault MH. Prediction
ofcreatinme clearance ftorn se creatimme. Nephrom 1976; 16:31-41.
Vestal RE, Wood Al, Shan DG. Rediced
beta? adren oceptoi sensitivity in the elderly. Clin Pharmacol Thei 1979; 26:181-186.
Castleden CM, George CF, Marcer D,
Hallett C. Increased sensitivity to nitrazepan in old age. BMJ 1977; 1: 10-11
Shepherd AM, Hewick DS, Moreland TA,
Stevenson IH. Age as a determinant of sensitivity to warfarin. BrJ Clin Pharmacol
1977;4:315-320.
Cadieux RJ. Drug interactions in the
elderly: how multiple drug use increases risk exponentially. Postgrad Med 1989 Dec. 86
179-186.
Nolan L. O'Malley K. Prescribing for
the elderly, 1. Sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc
1988. 36:142-149.
Gurwitz JH, Avorn J. The ambiguous
relation betwrrn agi rig and adverse drug reactions. Ann Intern Med 199LII4956-966.
Larmour 1, Dolphin RG, Baxter H.
Morrison S, Hooke DH McGrath BP. A prospective study of hospital admissions due to drug
reactions. Aust J Hosp Pharm 19911 21 90-95.
Lamy PP. Adverse drug effects. Clin
Geriatr Med 1990 May; 6:293 307.
Chrischilles EA Segar Et, Wallace RB,
Self-reported adverse drug recations and related resource use: a study of community-dwel
ling persons 65 years of age and older. Ann Intern Med 1992; 117:634-640.
Smith H, Janz TG, Erker M. Digoxin
toxicity presenting as altered mental status in a patient with severe chronic obtructive
lung disease. Heart Lung 1992; 21:78-80.
Passmore AP, Johnston GD. Digoxin
toxicity in the aged: characterising and avoiding the problem. Ding Aging 1991, 1 364-379.
Sommers DK, Reitz CL Koch Z, Avenant JC
Dogoxm withdrawal in patients with sinus rhythm. S Air Med 1 19811 60 239-240.
Macarthur C. Witdrawal of maintenance
dogoxin from institutionalized elderly. Postgrad Med J 1990; 66:940-942.
Lee DC, Johnson RA, Bingham JB, Leahy
M, Dinsmore RE, Goroll AH, et al. Heart failure in outpatients: a randomized trial of
dogoxin versus placebo. N Engl Med 1982; 306:699-705.
Smith TW, Dogitalis; mechanisms of
action and clinical use. N Frigl I Med 1988; 318:358-365.
Rodin SM, Johnson BF. Pharmacokinetic
onteractions with digoxin. Clin Pharmacokinet 1988: 15;227-244.
Cusack B, Kelly J, O'Malley K. Noel J.
Lavan J. Horgan J. Dogoxin in the elderly: pharmacokinetic consequences of old age. Clin
Pharmacol Ther 1979; 25:772-776.
Medication for the elderly. Drug Ther
Bull 1984; 22:49-52.
Williamson J. Chopin Jm. Adverse
reactions to prescribed drugs in the elderly: a multicentre investigation. Age Ageing
1980; 9:73-80.
Montamat SC, Abernethy DR. Calcium
antagonists in geriatric patients: diltiazem in elderly persons with hypertension. Clin
Pharmacol Ther 1989; 45:682-691.
Reynolds CF III, Kupfer DJ, Hoch CC,
Sewitch DE. Sleep-ing pills fortheelderly: are they ever justified? J Clin Psychiatry
1985; 46:9-12.
Mendelson WB. Pharmacotherapy of
insomnia. Psychiatr Clin North Am 1987 Dec: 10:555-563.
Drugs and insomnia: the use of
medications to promote sleep [Consensus Conference]. JAMA 1984; 251:2410-2414.
Caradoc-Davies TH. Nonsteroidal
anti-inflammatory drugs, arthritis, and gastrointestinal bleeding in elderly in-patients.
Age Ageing 1984; 13:295-298.
Wall R. Katschmski B. Logan R, Ashley
J, Langman M. Rising frequency of ulcer perfoartion inelderly people inthe United Kingdom.
Lancet 1986; 1:489-492.
Clive DM, Stuff JS. Renal syndromes
associated with nonsteroidal antiinflammatory drugs, N Engl J. Med 1984; 310:563-572.
Bianchi Porto G, Parente F. Long term
treatment of duodenal ulcera review of management options. Drugs 1991; 41:38-51.
Kitchin LI, Castell DO. Rationale and
efficacy of conservative therapy for gastroesophageal reflux disease. Arch Intern Med
1991; 151:448-454.
Schade RR. How physicians use
cimetidine: a survey of hospitalized patients and published cases, N Eng] J Med 1981;
304:1281-1284.
Sherman DS, Avorn J. Campion EW.
Cimetidine use in nursing homes: prolonged therapy and excessive doses. J Am Geriatr Soc
1987; 35 1023-1027.
Ulaszek KM, Seabloom KD, Sampliner RD,
Jones WN, Appropriatenes of long-term cimetidine prescribing. Drug Intell Clin Pharm 1984;
18:623-625.
Richter JM, Colditz GA, Huse DM,
DeleaTE, Oster G. Cimetidine and adverse reactions: a meta-analysis of randomized clinical
trials of shortterm therapy. Am J Med 19K 87:278-284.
