2) Freeman WH and col. The cancer problem. Readings from Scientific American. Cancer Biology. New York 1986; pág. 13. 3) Zambetti G, Levine A. A comparison of the biology activities of wild type and mutant P53. FASEB 1993; 7: 855. 4) Chang F, Syrjänen S, Kurvinen K, Syrjänen K. The p53 tumor suppressor gene as a common cellular target in human carcinogenesis. Am J Gastroenterol 1993; 88: 174-86. 5) Lane D. P53 guardian of the genome. Nature 1997; 389: 237-8, 300-9. 6) Radinsky R, Fidler IJ, Price JE, Esumi N, Tsan R, Petty CM y col. Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53. Oncogene 1994; 9:1877-83. 7) Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994; 54: 4855-78. 8) Harris A. Mutant p53: the commonest genetic abnormality in human cancer. J Pathol 1996; 162: 5-6. 9) Bruner J, Connely J, Saya H. P53 protein immunostaining in routinely processed paraffin embedded sections. Mod Pathol 1993; 6: 189-94. 10) Cooper H, Slemmer J. Surgical pathology of carcinoma of the colon and rectum. Semin Oncol 1991; 18: 367. 11) Wingo PA, Tong T, Bolden S. Cancer statistics, 1995. CA Cancer J Clin, 1995; 45: 8-30. 12) Jimenes G, Perez M, Nega H, Hano 0. Pesquistaje de lesiones precancerosas y cancerosas del colon en los trabajadores de asbesto. Rev Cub Hig Epidemiol 1995, Enero-Junio. 13) Willett WC, Stampfer MJ, Colditz GA, Rosner BA, Speizer FE. Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N Eng J Med 1990; 323: 1664. 14) Aschele C, Casazza D, Debernardis A y col. Lack of correlation between P53 overexpression and response to fura-based chemotherapy in advance colorectal cancer patients. Instituto Nazionale per la ricerca Sul Canero. Genova Italy 1997. Abstract 916 from Altavista. 15) Eddy D. Screening for colorectal cancer. Ann Int Med 1990; 113: 373-84. 16) Robbins S, Cotran R, Kurnar V. Patología estructural y funcional. 5ta edicion. Editorial Panamericana. México; 1995. pág. 2712. 17) Belluco C, Guillen J, Kemeny N, Huang Y, Klimstra D, Berger MF, Cohen AM. P53 nuclear protein overexpression in colorectal cancer: A dominant predictor of survival in patients with advanced hepatic metastases. J Clin Oncol 1996; 14(10): 2696-701. 18) Fante R, Di Gregorio, Losi L, Roncucci L, Ponz de Leon M. Clinicopathological correlation and prognostic significance of nuclear p53 protein in colorectal cancer. Ital J Gastroenterol 1996; 28(4): 20510. 19) Sasaki K, Sato T, Kurose A, Ikeda E. Immunohistochemical detection of P21 waf 1/CIP1/SDI1 and P53 sections of colorectal carcinoma. Human Pathol 1996; 27(9): 912-6. 20) Liang Z, Liu F, Luo Y. Detection of the expression of P21, P53, P185 proteins and mutation in colorectal adenoma and carcinoma. Chung Hua Ping Li Hsueh Chin 1995; 24(6): 352-5. 21) Poller D, Baxter K, Shepherd N. P53 and RBi protein expression: Are they prognostically useful in colorectal cancer? Br J Cancer 1997; 75(l): 87-93. 22) Spitz F, Nguyen D, Skibbert J, Meyn R, Cristiano RJ, Roth JA. Adenoviral mediated P53 gene therapy enhances radiation sensitivity. Proc Annu Meet. Am Assoc Cancer Res 1996; 37: A2366. 23) Starsynska T, Bromley M, Marlicz K, Roberts SA, Vcinsk M, Stern P. Accumulation of p53 in relation to long-term prognosis in colorectal carcinoma. Eur J Gastroenterol Hepatol 1997; 9(2): 183-6. 24) Flamini G, Cuvigliano G, Ratto C, Astone A, Ferreti G, Nucera P, Sofo L, Sgambato A, Boninsegna A, Crucitti F, Cittadini A. Prognostic significance of cytoplasmic P53 overexpression in colorectal cancer an immunohistochemical analysis. Eur J Cancer 1996; 32(5): 802-6. 25) Darmon E, Cleary K, Wargovich M. Immunohistochemical analysis of P53 overexpression in human colonic tumors. Cancer Detect Prev 1994; 18(3): 187-95. 26) Pereira H. Silva S, Juliao R, Garcia P, Perpetua F. Prognostic markers for colorectal cancer expression of P53 and BCL 2. World J Surg 1997; 21(2): 210-3. 27) El Mandani N, Vaillant J, Guiguet M, Prevot S, Bertrand V, Bernard C, Pare R, Bereziat G, Hermelin B. Overexpression of P53 mRNA in colorectal cancer an its relationship to P53 gene mutation. Br J Cancer 1996; 74(4): 528-36. |